Toronto: Exercising to improve your cardiovascular strength may protect from cognitive impairment as you age, according to a new study.
Researchers at the University of Montreal and its affiliated Institut universitaire de geratrie de Montreal Research Centre studied 31 young people between the ages of 18 and 30 and 54 older participants aged between 55 and 75.
"Our body's arteries stiffen with age, and the vessel hardening is believed to begin in the aorta, the main vessel coming out of the heart, before reaching the brain," said Claudine Gauthier, first author of the study.
"Indeed, the hardening may contribute to cognitive changes that occur during a similar time frame.
"We found that older adults whose aortas were in a better condition and who had greater aerobic fitness performed better on a cognitive test.
"We therefore think that the preservation of vessel elasticity may be one of the mechanisms that enables exercise to slow cognitive ageing," Gauthier said.
The researchers compared the older participants within their peer group and against the younger group who obviously have not begun the ageing processes in question.
None of the participants had physical or mental health issues that might influence the study outcome.
Their fitness was tested by exhausting the participants on a workout machine and determining their maximum oxygen intake over a 30 second period. Their cognitive abilities were assessed with the Stroop task.
The Stroop task is a scientifically validated test that involves asking someone to identify the ink colour of a colour word that is printed in a different colour.
A person who is able to correctly name the colour of the word without being distracted by the reflex to read it has greater cognitive agility.
The participants undertook three MRI scans: one to evaluate the blood flow to the brain, one to measure their brain activity as they performed the Stroop task, and one to actually look at the physical state of their aorta.
The researchers were interested in the brain's blood flow, as poorer cardiovascular health is associated with a faster pulse wave, at each heartbeat which in turn could cause damage to the brain's smaller blood vessels.
The results demonstrated age-related declines in executive function, aortic elasticity and cardiorespiratory fitness, a link between vascular health and brain function, and a positive association between aerobic fitness and brain function.
"The link between fitness and brain function may be mediated through preserved cerebrovascular reactivity in periventricular watershed areas that are also associated with cardiorespiratory fitness," Gauthier said.
"Heart Mate II was implanted through a complex procedure.
The surgery opens new avenues for not only Indian but also international patients awaiting heart transplants. Delhi pioneered the first heart transplant, yet the southern states have developed a far better coordinated mechanism for organ donations and transplants. Innovative use of technology, such as this, will help in bridging the demand and supply gap," said Dr Seth.
Unlike a heart transplant which requires intake of immuno-suppressants to facilitate organ acceptance, patients with implanted device need to take only one simple blood thinning medicine to ensure free flow of blood.
Another advantage is that the device can be removed if the left ventricle recovers in due course of time. Furthermore, patient with rare blood groups can also benefit from the implant as same device is inter-operable with all blood groupings.
As the technology matures and the devices become miniaturized, future devices can be completely implanted inside the human body.
As per FDA certification, the expected longevity of the device is 60 years.
The burden of heart failure in India is high, roughly estimated close to 5 million and due to lack of availability of deceased donor hearts the problem is even more insurmountable in current scenario, said Attawar.
